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Pubblicazioni Aperte DIgitali Sapienza > Scienze biochimiche "A. Rossi Fanelli" > BIOCHIMICA >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10805/1300

Title: identification of molecular targets in the human genome
Authors: LEONI, GUIDO
Tutor: Tramontano, Anna
Keywords: alternative splicing
bioinformatic
tocotrienols
vitamin E
Issue Date: 2012
Abstract: The purpose of the present study is to contribute to the field of functional genomics by developing, testing and applying computational methods to the problem of the evaluation of the effects of environmental and pharmacological molecules on genome expression. Original results are described in four independent sections The first two sections are devoted to the investigation of the coding potential of alternative splicing products in the human genome. Sections three and four are devoted to the application of computational techniques to investigate the molecular targets and the effects on their expression of molecules known to interfere with the physiological functions of a cell. In particular these techniques were applied on a class of compounds (tocotrienols) constituents of the Vitamin E.
URI: http://hdl.handle.net/10805/1300
Research interests: Bioinformatics, biochemistry, computational biology applied to nutrition
Personal skills keywords: perl programmer
bioinformatician
skills in analysis of transcriptomic expression data
Appears in PhD:BIOCHIMICA

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File Description SizeFormat
TesiGuidoLeonicopiaelettronica.pdfTesi Dottorato in Biochimica7.86 MBAdobe PDF

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CurriculumVitae.doc 70.21 kBMicrosoft Word


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