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Pubblicazioni Aperte DIgitali Sapienza > Scienze anatomiche, istologiche, medico-legali e dell'apparato locomotore > SCIENZE E TECNOLOGIE CELLULARI >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10805/1616

Title: PACAP function during rat folliculogenesis
Authors: LATINI, STEFANIA
Tutor: Canipari, Rita
Keywords: Ovary
Folliculogenesis
PACAP
Rat
Primordial follicles
Issue Date: 6-Apr-2009
Abstract: Pituitary adenylate cyclase activating polypeptide (PACAP) is transiently expressed in preovulatory follicles of different species and positively affects parameters correlated with the ovulatory process. The aim of this study was to investigate whether PACAP influences the recruitment of primordial follicles and the growth and differentiation of preantral follicles. Rat ovaries from 2-day-old animals were cultured for 5 days in the presence of PACAP. This treatment significantly inhibited the primordial to primary follicle transition. PACAP inhibited granulosa cell proliferation without affecting cell viability. PACAP also inhibited the growth of isolated preantral follicles cultured under basal conditions or in the presence of follicle-stimulating hormone (FSH). These results suggest that PACAP is significantly involved in the cyclic recruitment of primordial follicles and in the FSH-dependent growth of preantral follicles.
URI: http://hdl.handle.net/10805/1616
Appears in PhD:SCIENZE E TECNOLOGIE CELLULARI

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