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Pubblicazioni Aperte DIgitali Sapienza > Neurologia e psichatria > NEUROSCIENZE, CHIRURGIA MAXILLO-FACCIALE E PATOLOGIA DEL SISTEMA UDITIVO >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10805/1824

Title: EFFETTI DEL TOPIRAMATO SULLA VASOREATTIVITA' CEREBRALE VALUTATA MEDIANTE DOPPLER TRANSCRANICO IN PAZIENTI AFFETTI DA EMICRANIA CON E SENZ'AURA DURANTE IL PERIODO INTERICTALE
Authors: RICCIARDI, MARIA CHIARA
Tutor: Lenzi, Gian Luigi
Keywords: Cerebral vasoreactivity
Transcranial Doppler ultrasonography
Topiramate
Migraine
Issue Date: 22-May-2012
Abstract: Interictal cerebrovascular reactivity to hypercapnia and middle cerebral arteries (MCA) mean flow velocities were investigated in 20 patients with high-frequency migraine (8 with aura and 12 without aura) and 19 age and sex-matched healthy controls by means the CO2 reactivity test. Patients were started on prophylactic treatment with topiramate 100 mg per day, and measurements were repeated after 8 weeks treatment. Baseline mean blood flow velocities were not different in the controls and patients. Cerebrovascular reactivity (VMR), calculated as the percentage increase in MCA velocity during the 90 seconds inhalation of a mixture of 7% CO2/air, was found to be significantly greater (p < 0.01) in both patient groups compared with the controls, showing an exaggerated reactivity to hypercapnia in migraineurs. Cerebrovascular reactivity to hypercapnia improved significantly after preventive treatment (p < 0.001), and the baseline difference in VMR values between the pre-treatment migraine group and the control group was no longer evident at 2 months.
URI: http://hdl.handle.net/10805/1824
Research interests: Stroke;Transcranial Doppler; Carotid plaque characterization; Cerebral vasoreactivity; Migraine
Personal skills keywords: Migraine;
Cerebral vasoreactivity;
Transcranial Doppler ultrasonography
Appears in PhD:NEUROSCIENZE, CHIRURGIA MAXILLO-FACCIALE E PATOLOGIA DEL SISTEMA UDITIVO

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