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Please use this identifier to cite or link to this item: http://hdl.handle.net/10805/1844

Title: Chiral Supramolecular Chemistry of Basket Resorc[4]arenes
Authors: CALCATERRA, ANDREA
Tutor: FILIPPI, ANTONELLO
Keywords: Chiral
Resorc[4]arenes
Mass Spectrometry
DOSY
IRMPD
NMR
Host
Guest
Complex
enantiodiscrimination
ROESY
Issue Date: 11-Feb-2013
Abstract: Chiral Basket Resorc[4]arenes are well known chiral solvating agents that can induce enantiodiscrimination towards aminoacids, peptides and nucleosides. We synthesized both enantiomer of some basket resorc[4]arenes capable of forming stable diasteromeric host-guest complexes with some nucleosides like cytidine and cytarabine. The reactivity and the structures of the complexes were investigated in gas-phase (ESI-IRMPD, ESI-FT-ICR) and in solution (DOSY, ROESY). Different "in" and "out" structures were found both in solution and in gas-phase, moreover the results were supported by theoretical calculations.
URI: http://hdl.handle.net/10805/1844
Research interests: Shintesis and purification of bioactive natural products and of pharmaceutical intermediates by enzimatic or transition metals catalysis.
Personal skills keywords: Synthesis and purification
MS, ESI-FTICR
HPLC-UV
GC-MS
Appears in PhD:SCIENZE FARMACEUTICHE

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