PADIS

Pubblicazioni Aperte DIgitali Sapienza > Chimica e tecnologie del farmaco > SCIENZE FARMACEUTICHE >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10805/1859

Title: Development of a Novel Class of Pharmacodynamic Hybrids/NO Donors that Targets COX-2 Selectively and a Machine-Assisted Flow Procedure for the Synthesis of Meclinertant, a Neurotensin Receptor Probe
Authors: BATTILOCCHIO, CLAUDIO
Tutor: Biava, Mariangela
Keywords: Flow Chemistry
Analgesic and Antiinflammatory agents
Issue Date: 12-Feb-2013
Abstract: The work described below is divided into two parts. In the first chapter, the development of a novel class of pharmacodynamic hybrids is discussed. These compounds are endowed with analgesic/anti-inflammatory properties along with their ability to release nitric oxide which makes them an important contribution to the development of effective COX-Inhibiting Nitric Oxide Donors. In the second chapter, the synthesis of an important neurotensin receptor antagonist (SR 48692, Meclinertant) is described. The synthesis of Meclinertant is achieved with the use of machine-assisted flow protocols through a robust, reliable and scalable route.
URI: http://hdl.handle.net/10805/1859
Research interests: Synthetic organic chemistry, flow chemistry, medicinal chemistry
Personal skills keywords: Machine-assisted synthesis
Batch-mode synthesis
Appears in PhD:SCIENZE FARMACEUTICHE

Files in This Item:

File Description SizeFormat
Claudio_Battilocchio_PhD_Thesis.pdf5.86 MBAdobe PDF

File del Curriculum Vitae:

CurriculumVitae.pdf 142.59 kBAdobe PDF


This item is protected by original copyright

Recommend this item

Items in PADIS are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2010  Duraspace - Feedback Sviluppo e manutenzione a cura del CINECA