Pubblicazioni Aperte DIgitali Sapienza > Chimica e tecnologie del farmaco > SCIENZE FARMACEUTICHE >

Please use this identifier to cite or link to this item:

Title: Synthesis and biological evaluation of new potential co-adjuvants for the treatment of Parkinson’s disease and a new catalytic, asymmetric approach to the synthesis of fused heterocycles of biological interest.
Tutor: Bolasco, Adriana
Keywords: Parkinson's disease
Phase Transfer Catalysis
Issue Date: 12-Feb-2013
Abstract: Medicinal chemistry and pure organic chemistry were merged in this thesis as two faces of the same coin. In the first part, more than a hundred hydrazothiazole derivatives were synthesized and tested as human monoamine oxidase B selective inhibitors in order to define accurate structure activity relationships. Our knowledge on human MAO-B inhibition was then applied to the synthesis of purine derivatives as potential dual human MAO-B inhibitors and adenosine A2A receptor antagonists. In the second part, the search for a new catalytic, asymmetric route to the synthesis of poly(hetero)cyclic compounds of biological interest led to the development of a new enantioselective approach to the phase transfer catalyzed cyclization of pyrrole derived substrates.
Research interests: Medicinal Chemistry, Small Molecules, Diversity Oriented Synthesis, Organic Chemistry, Organocatalysis
Skills short description: Confident and efficient in the lab, competent in organic and medicinal chemistry, entusiastic and propositive. Able to work independently and in team.
Personal skills keywords: Accurate

Files in This Item:

File Description SizeFormat
Melissa D'Ascenzio_PhD thesis.pdfPhD Thesis7.81 MBAdobe PDF

File del Curriculum Vitae:

CurriculumVitae.docx 37.43 kBMicrosoft Word XML

This item is protected by original copyright

Recommend this item

Items in PADIS are protected by copyright, with all rights reserved, unless otherwise indicated.


Valid XHTML 1.0! DSpace Software Copyright © 2002-2010  Duraspace - Feedback Sviluppo e manutenzione a cura del CINECA