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Please use this identifier to cite or link to this item: http://hdl.handle.net/10805/1929

Title: Synthesis and biological evaluation of new potential co-adjuvants for the treatment of Parkinson’s disease and a new catalytic, asymmetric approach to the synthesis of fused heterocycles of biological interest.
Authors: D'ASCENZIO, MELISSA
Tutor: Bolasco, Adriana
Keywords: Parkinson's disease
Phase Transfer Catalysis
Issue Date: 12-Feb-2013
Abstract: Medicinal chemistry and pure organic chemistry were merged in this thesis as two faces of the same coin. In the first part, more than a hundred hydrazothiazole derivatives were synthesized and tested as human monoamine oxidase B selective inhibitors in order to define accurate structure activity relationships. Our knowledge on human MAO-B inhibition was then applied to the synthesis of purine derivatives as potential dual human MAO-B inhibitors and adenosine A2A receptor antagonists. In the second part, the search for a new catalytic, asymmetric route to the synthesis of poly(hetero)cyclic compounds of biological interest led to the development of a new enantioselective approach to the phase transfer catalyzed cyclization of pyrrole derived substrates.
URI: http://hdl.handle.net/10805/1929
Research interests: Medicinal Chemistry, Small Molecules, Diversity Oriented Synthesis, Organic Chemistry, Organocatalysis
Skills short description: Confident and efficient in the lab, competent in organic and medicinal chemistry, entusiastic and propositive. Able to work independently and in team.
Personal skills keywords: Accurate
Competent
Motivated
Efficient
Indipendent
Appears in PhD:SCIENZE FARMACEUTICHE

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