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Pubblicazioni Aperte DIgitali Sapienza > Biologia e Biotecnologie "Charles Darwin" > BIOLOGIA CELLULARE E DELLO SVILUPPO >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10805/2408

Title: Transcriptional Regulation and Function of NLRP12
Authors: TUNCER, SINEM
Keywords: NLRP12
differentiation
monocyte
cell cycle
Issue Date: 27-Feb-2014
Abstract: Nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) are evolutionarily conserved intracellular PRRs (Pattern Recognition Receptors) that play an important role in host defense and physiology. NLRP12 is a NLR protein which is expressed predominantly in cells of myeloid origin. Because NLRP12 expression is restricted to immune cells and its expression is down-regulated in response to pathogens, pathogen products and inflammatory cytokines, it has been predicted that NLRP12 functions in regulating inflammation and immunity. Although NLRP12 was one of the earliest identified NLRPs, its precise function(s) is not fully understood as yet. Despite the increasing number of publications, the role of NLRP12 remains ambiguous because of conflicting results. In this PhD thesis, the regulation of NLRP12 promoter activity by NF-B, the transcriptional modulation of NLRP12 expression during myeloid cell lines and primary monocytes stimulation/differentiation as well as the effects of NLRP12 over-expression on the growth of monocytic cell line U937 are reported.
URI: http://hdl.handle.net/10805/2408
Appears in PhD:BIOLOGIA CELLULARE E DELLO SVILUPPO

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