PADIS

Pubblicazioni Aperte DIgitali Sapienza > MEDICINA SPERIMENTALE > PATOLOGIA UMANA >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10805/2585

Title: PTHrP and PTH1R expression in Human myocardiocytes.
Other Titles: Espressione del PTHrP e del PTHR1 nei miocardiociti umani
Authors: STIGLIANO, EGIDIO
Tutor: Chimenti, Cristina
Keywords: PTHrP
PTHR1
cardiomyocytes
autoptical
Issue Date: 5-Feb-2013
Abstract: The PTHrP/PTH1R signalling system induces calciotropic and myorelaxant effects on the vascular system and plays critical roles in the development of the cardiovascular system. In animal models, PTHrP exerts important effects on heart rate and contractility, particularly under ischemic conditions, while, in human hearts, the expression of PTHrP by cardiomyocytes remains to be defined in both normal and ischemic conditions. The present study has been conducted on 101 autoptical cases and confirmed on nine explanted hearts in order to analyze the expression of the PTHrP/PTH1R system by ventricular myocardium in respect to morphological aspects of the myocardial ischemic damage, myofiber hypertrophy and disarray, coronarosclerosis, age and sex. Immunohistochemistry showed positive cytoplasmic immunostaining for both PTHrP and PTH1R in ventricular cardiomyocytes. The expression levels of the PTHrP/PTH1R system resulted significantly increased (P = 0.0008 and P < 0.0001, respectively) in association with the myocardial ischemic damage and the presence of cardiomyocyte hypertrophy (P = 0.02 and P = 0.009 respectively). Conversely, increased expression levels of PTHrP alone were observed in myofiber disarray (P = 0.04), whereas PTH1R was augmented in coronarosclerosis (P = 0.004) and age (P = 0.001). Taken together, these results demonstrate that human ventricular cardiomyocytes express PTHrP and PTH1R and suggest that the activation of the PTHrP/PTH1R system could represent an aspect of the embryonic gene program typically reactivated by the myocardium when subjected to ischemia and/or hypertrophy.
URI: http://hdl.handle.net/10805/2585
Appears in PhD:PATOLOGIA UMANA

Files in This Item:

File Description SizeFormat
tesi_dottorato_egidio_stigliano.pdf1.4 MBAdobe PDF


This item is protected by original copyright

Recommend this item

Items in PADIS are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2010  Duraspace - Feedback Sviluppo e manutenzione a cura del CINECA