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|Title: ||Characterization of Cellular Functions in Leukemias|
|Authors: ||Peragine, Nadia|
|Tutor: ||Guarini, Anna|
|Keywords: ||Chronic Lymphocytic Leukemia|
Haematopoietic stem cell transplantation
Regolatory T cells
Acute Lymhoblastic Leukemia
|Issue Date: ||12-Jul-2010|
|Research interests: ||-Phenotypic and functional characterization of monocyte-derived dendritic cells from Acute Lymphoid Leukemia (ALL) patients in complete remission or on Imatinib maintenance, with the aim of designing a therapeutic vaccine.
-Analysis of Chronic Lymphocytic Leukemia (CLL) cell pro-angiogenetic properties.
-Analysis of primary leukemic ALL and CLL cell sensitivity to in vitro Dasatinib (BMS-354825) treatment.
-Analysis of the effects of in vitro CLL cell stimulation with antibodies directed towards surface IgM and IgD B-cell receptor (BCR) isotypes.
-Characterization of regulatory T (Treg) cells isolated from umbilical cord blood.
-Characterization of Treg cells isolated from patient with hematological malignancies who had undergone allogeneic stem cell transplantation.
-Interest on detecting p53 dysfunctions in leukemic B-cells from CLL patients in different phases of the disease.|
|Skills short description: ||-Cell cultures
|Personal skills keywords: ||Chronic Lymphocytic Leukemia|
B-cell antigenic stimulation
In vitro drug sensitivity
Dendritic cell- and Treg cell-based Immunotherapy
|Appears in PhD:||SCIENZE EMATOLOGICHE|
Files in This Item:
|Tesi Dottorato Nadia Peragine 12-07-2010.pdf||Tesi di Dottorato di Ricerca in Scienze Ematologiche||3.33 MB||Adobe PDF|
File del Curriculum Vitae:
|CurriculumVitae.pdf|| ||421.7 kB||Adobe PDF|
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